The Buffalo Bills are reeling coming off a pair of losses to open the season http://www.buffalobillsteamonline.com/jordan-poyer-jersey , and while Buffalo is looking to shock the football world Sunday with a win over the reigning NFC North champion Minnesota Vikings, the Las Vegas oddsmakers don't like Buffalo's chances. Buffalo (0-2) opened as a 16.5-point underdog vs. Minnesota, a disparity that is the second-biggest between two teams dating back to the 2003 season. The road to that first win doesn't get any easier Sunday, as the Bills travel to U.S. Bank Stadium in Minneapolis, a traditionally tough place to play with its raucous fans and loud atmosphere. As if it wasn't enough that the Bills are struggling mightily on defense, having allowed 78 points in back-to-back losses to the Baltimore Ravens and Los Angeles Chargers, the offense, led by rookie Josh Allen, must now attempt to solve a riddle that has befuddled many a rookie quarterback in the past: how to beat a Mike Zimmer-coached defense. A HUGE area of concern for Bills fans is how Allen, who is making the first road start of his career, will respond playing an elite defense in a hostile atmosphere. The last five times a rookie quarterback has squared off against a Mike Zimmer-coached defense, they have failed to pass for more than 180 yards in a game. While two rookies won their showdowns with Minnesota, it wasn't because of their passing prowess. During their rookie seasons, Mitchell Trubisky (twice), DeShone Kizer, Carson Wentz, and Dak Prescott combined to complete 55 percent of their passes while logging three touchdown passes and three interceptions. Together, they passed for 762 yards, an average of 152.4 passing yards per game. Here are the stat lines and the game results for the last five games where a rookie quarterback took on the Vikings: Oct. 23, 2016: Wentz: 16-of-28 passing for 138 yards, 1 TD, 2 INTs, 0 sacks. Philadelphia Eagles won 21-10. Dec. 1, 2016: Prescott: 12-of-18 passing for 139 yards Womens Ryan Groy Jersey , 1 TD, 0 INTs, 3 sacks. Dallas Cowboys won 17-15. Oct. 9, 2017: Trubisky: 12 of 25 passing for 128 yards, 1 TD, 1 INT, 1 sack. Chicago Bears lost 20-17. Oct. 29, 2017: Kizer: 18-of-34 passing for 179 yards, 0 TDs, 0 INTs, 3 sacks. Cleveland Browns lost 33-16. Dec. 31, 2017: Trubisky: 20-of-36 passing for 178 yards, 0 TDs, 0 INTs, 1 sack. Chicago Bears lost 23-10.Here's hoping Allen can fare better Sunday than these previous rookie signal-callers did in Minnesota.Marlon Humphrey among Baltimore Ravens to watch vs Buffalo Bills The Buffalo Bills face a difficult task in the first week of the 2018 NFL season, traveling to Maryland to take on the Baltimore Ravens. The Ravens feature a revamped offense, and their defense appears to be primed to return to past glories, at least on paper. There are plenty of opponents worth watching this weekend. If the Bills can control these five, they will exponentially increase their chances of starting the season with a victory.CB Marlon HumphreyThe second-year man steps into the starting lineup for the month of September, replacing veteran Jimmy Smith. Smith is serving a four-game suspension for a violation of the league's personal conduct policy stemming from a domestic violence incident involving a former girlfriend. Humphrey, who served as Baltimore's third corner last season, will now be tasked with starting on the outside. Veteran Brandon Carr is Baltimore's other starting corner, but if the Bills can exploit the young player's inexperience, they may be able to find some early rhythm in the passing game. That rhythm is essential for Nathan Peterman to find success.WR John BrownThe Ravens changed up their entire receiving corps this year. Gone are Mike Wallace Womens Vladimir Ducasse Jersey , Breshad Perriman, and Jeremy Maclin. In their place are Michael Crabtree, Willie Snead IV, and Brown. Assuming that Buffalo's top corner, Tre'Davious White, shadows Crabtree, if anyone at all, that leaves Brown to square off against Vontae Davis or Phillip Gaines. Each player struggled in the preseason, so Brown could be in line for a big day. The Bills will need to find a way to contain Baltimore's new-look passing attack if they want to come out victorious on Sunday.EDGE Terrell SuggsThe veteran sack master has been a thorn in the side of NFL offensive lines since Baltimore drafted him in the first round of the 2003 NFL Draft. Even at 35 years old, he remains a formidable pass rusher, having recorded his seventh double-digit sack season in 2017. The Ravens move Suggs all around the defense, and the Bills would be wise to ensure that both of their tackles—Dion Dawkins on the left side and Jordan Mills on the right side—have help when trying to control him. If they can neutralize him, they'll give Peterman a chance to succeed.QB Joe FlaccoBaltimore's $100 million dollar man had one of the worst years of his career last season, averaging only 5.7 yards per attempt on his way to his lowest overall yardage total (3,141) for a 16-game season since his rookie year. Rather than move on from Flacco, the Ravens gave him different offensive weapons, including the three aforementioned receivers and two new tight ends in Mark Andrews and Hayden Hurst. While Baltimore did draft quarterback Lamar Jackson in the first round as a developmental project, the team clearly isn't ready to replace its Super Bowl-winning quarterback quite yet.C Matt SkuraThe Ravens lost starter Ryan Jensen when he signed a lucrative free-agent contract this off season with the Tampa Bay Buccaneers, leaving the starting center position in Baltimore to be filled by Skura. The third-year player entered the league as an undrafted free agent out of Duke, signing with Baltimore following the 2016 NFL Draft. Jensen was a fantastic pivot during his time with the Ravens, and the Bills are strong up the middle with Kyle Williams and Star Lotulelei ready to play this week. The key to controlling Baltimore's run game is winning in the trenches, and overpowering the first-time starter in the middle could be Buffalo's best pathway to success.